p21Cip1 Confers resistance to imatinib in human chronic myeloid leukemia cells

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BACKGROUND/AIMS The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed, and a substantial number of patients need alternative treatment strategies. METHODS We have evaluated the effects of deferasirox, an orally active iron chelator...

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ژورنال

عنوان ژورنال: Cancer Letters

سال: 2010

ISSN: 0304-3835

DOI: 10.1016/j.canlet.2009.11.017